Publications

T = Technician, U = Undergraduate Student, G = Graduate Student, P = Postdoctoral Fellow in my lab

2020

Dent E.W. (2020) Dynamic microtubules at the synapse. Current Opinion in Neurobiology. 63:9-14. PMCID: PMC7423735, Pubmed

Taylor R.J.G, Carrington J.U, Gerlach L.R.U, Taylor K.L.G, Richters K.E.T and E.W. Dent (2020) Double UP: a dual color, internally controlled platform for in utero knockdown or overexpression. Frontiers in Molecular Neuroscience. 13:82. PMCID: PMC7251070, Pubmed

Uppakara K., Jamornwan S., Duan L., Yue K., Sunrat C., Dent E.W., Wan S. and W. Saengsawang (2020) A novel alpha-lipoic acid-3-n-butylphthalide conjugate enhances protective effects against oxidative stress and 6-OHDA induced neuronal damage. ACS Chem Neurosci. Jun 3;11(11):1634–1642. PMID: 32374999. Pubmed

2019

Taylor K.L.G, Taylor R.J.G, Richters K.E.T, Huynh B.U, Carrington J.U, McDermott M.E.U, Wilson R.L.U and E.W. Dent (2019) Opposing functions of F-BAR proteins in neuronal membrane protrusion, tubule formation, and neurite outgrowth. Life Science Alliance. Jun 3;2(3). PMCID: PMC6549137. PubMed

2018

Kim H., Lee I.K., Taylor K.G, Richters K.T, Baek D.H., Ryu J.H., Cho S.J., Jung Y.H., Park D.W., Novello J., Bong J., Suminski A.J., Dingle A.M., Blick R.H., Williams J.C., Dent E.W. and Ma Z. (2018) Single-neuronal cell culture and monitoring platform using a fully transparent microfluidic DEP device. Scientific Reports. Sep 4;8(1):13194. PMCID: PMC6123457. PubMed

2017

Dent, E.W. (2017) Of microtubules and memory: Implications for microtubule dynamics in dendrites and spines. Molecular Biology of the Cell, 28:1-8. PMCID: PMC5221613. PubMed

2016

McVicker D.P.P, Awe A.M.U, Richters K.E.T, Wilson R.L.U, Cowdrey D.A.T, Hu X.G, Chapman E.R. and E.W. Dent (2016) Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity. Nature Communications. 7:12741. PMCID: PMC5411814. PubMed.

Winkle, C.C., K.L. TaylorG, E.W. Dent, G. Gallo, K. Greif and S.L. Gupton (2016) The emerging role of membrane turnover and organelles in the regulation of axon collateral branches. Developmental Neurobiology, 76:1293-1307. PMCID: PMC5079834. PubMed.

Forbes-Lorman, R., M.A. Harris, W.S. Chang, E.W. Dent, E.V. Nordheim and M.A. Franzen (2016) Physical models have gender-specific effects on student understanding of protein structure-function relationships. Biochemistry and Molecular Biology Education, 44:326-35. PMCID: PMC4936926. PubMed

Nichol, R.H., K.M. Hagen, D.C. LumbardT, E.W. Dent and T.M. Gomez (2016) Guidance of axons by local coupling of retrograde flow to point contact adhesions. J Neuroscience, 36: 2267-82. PMCID: PMC4756158. PubMed

Ukken, F.P., J.J. Burckner, K.L. Weir, S. Sison, R.M Birschback, S.J. Hope, L. Hicks, K.L. TaylorG, E.W. Dent, G.B. Gonsalvez and K.M. O’Connor-Giles. (2016) SH3-BAR sorting nexins are conserved nervous wreck interactors that organize synapses and promote neurotransmission. J Cell Science, 129: 166-77. PMCID: PMC4732300. PubMed


2015

McVicker, D.P.P, M.M. MilletteG and E.W. Dent (2015) Signaling to the microtubule cytoskeleton: An unconventional role for CaMKII. Developmental Neurobiology. 75:423-34. PMCID: PMC4340821. PubMed


2014

Li, L.*, T. FothergillP*, B.I. Hutchins, E.W. Dent and K. Kalil (2014) Wnt5a evokes cortical axon outgrowth and repulsive guidance by tau mediated reorganization of dynamic microtubules. (* equal contributions) Dev Neurobiology. 74:797-817. PMCID: PMC4087151. PubMed

Kalil, K. and E.W. Dent (2014)Branch management: mechanisms of axon branching in the developing vertebrate CNS.Nature Reviews Neuroscience, 15:7-18. PMCID: PMC4063290. PubMed

Cavallo, F., Y. Huang, E.W. Dent, J.C. Williams and M.G. Legally (2014) Neurite guidance and three-dimensional confinement via compliant semiconductor scaffolds. ACS Nano, 8:12219-27. PubMed


2013

Merriam, E.BG., M. MilletteG, D.C. LumbardT, W. SaengsawangP, T. FothergillP, X. HuG, L. Ferhat and E.W. Dent (2013)Synaptic regulation of microtubule dynamics in dendritic spines by calcium, F-actin and drebrin. J Neuroscience, 33: 16471-16482. PMCID:PMC3797370. PubMed

Saengsawang, WP., K.L. TaylorG, D.C. LumbardT, K. MitokU, A. PriceU, L. PietilaU, T.M. Gomez and E.W. Dent (2013) CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils. Journal of Cell Science, 126:2411-2423. PMCID:PMC3679485. PubMed

Beetz, C., A. Johnson, A.L. Schuh, S. Thakur, R-E Varga, T. FothergillP, N. Hertel, E. Bomba-Warczak, H. Thiele, G. Nurnberg, J. Altmuller, R. Saxena, E.R. Chapman, E.W. Dent, P. Nurnberg ad A. Audhya (2013) Inhibition of TFG function causes hereditary axon degeneration by impairing ER structure. PNAS, 110:5091-5096. PMCID: PMC3612678.PubMed

Hart, S.R., Y. Huang, T. FothergillP, D.C. LumbardT, E.W. Dent and J.C. Williams (2013) Adhesive micro-line periodicity determines guidance of axonal growth. Lab on a Chip, 13:562-569. PMCID: PMC4123686. PubMed


2012

Saengsawang, W.P, K. MitokU,C. ViesselmannU, L. PietilaU, D. LumbardU, S.J. Corey and E.W. Dent (2012) The F-BAR protein CIP4 inhibits neurite formation by producing lamellipodial protrusions. Current Biology, 22:494-501. PMCID: PMC3311763 PubMed


2011

Merriam, E.B.G, D.C LumbardU, C. ViesselmannU, J. BallwegU, M. StevensonU, L. PietilaU, X.G. HuG and E.W. Dent (2011) Dynamic microtubules promote NMDA receptor-dependent spine enlargement. PLoS One, 6(11); e27688.doi:10.1371/journal.pone.0027688. PMCID: PMC3214068 PubMed

E.W. Dent,. E.B. Merriam and X Hu. (2011) The dynamic cytoskeleton: Backbone of dendritic spine plasticity. Current Opinions in Neurobiology, 21:175-81 PubMed

Dent, E.W., S.L. Gupton and F.B. Gertler (2011) The growth cone cytoskeleton in axon outgrowth and guidance,In: Wiring the brain the biology of neuronal guidance.A. Kolodkin and M. Tessier-Lavigne, eds. Cold Spring Harbor, NY PubMed

C. Viesselmann, J. Ballweg, D. Lumbard, E.W. Dent (2011) Nucleofection and primary culture of embryonic mouse hippocampal and cortical neurons. J Vis. Exps., 47http://www.jove.com/details.stp?id=2373doi: 10.3791/2373 PubMed

Hu, X.G.G, L. BalloU, L. PietilaU, C. ViesselmannU, J. BallwegU, D. LumbardU, M. StevensonU, E. MerriamG and E.W. Dent (2011) BDNF-induced increase of PSD-95 in dendritic spines requires dynamic microtubule invasions.J Neuroscience, 31:15597-603. PMCID: PMC3224154 PubMed

Yu, M., Y. Huang, J. Ballweg, H. Shin, M. Huang, D.E. Savage, M.G. Lagally, E.W. Dent, R.H. Blick and J.C. Williams (2011) Semiconductor nanomembrane tubes: Three dimensional confinements for controlled neurite outgrowth. ACS Nano, 5:2447-57 PubMed

Staii, C., C. Viesselmann, J. Ballweg, J.C. Williams, E.W. Dent, S.N. Coppersmith, M.A. Eriksson (2011) Distance dependence of neuronal growth on nanopatterned gold surfaces. Langmuir, 27:233-39 PubMed


2009

Staii, C., C. Viesselmann, J. Ballweg, L. Shi, G-Y Liu, J.C. Williams, E.W. Dent, S.N. Coppersmith, M.A. Eriksson (2009) Positioning and guidance of neurons on gold surfaces by directed assembly of proteins by atomic force microscopy. Biomaterials, 30:3397-3404 PubMed


2008

Hu, X.G., C. Viesselmann, S. Nam, E. Merriam and E.W. Dent (2008) Activity-Dependent dynamic microtubule invasion of dendritic spines.Journal of Neuroscience, 28: 13094-13105 PubMed


2007

Dent, E.W., A.V. Kwiatkowski, L. Mebane, U. Philippar, M. Barzik, D.A. Rubinson, S. Gupton, J.E. van Veen, C. Furman, J. Zhang, A. Alberts, S. Mori and F.B. Gertler (2007) Filopodia are required for cortical neurite initiation.Nature Cell Biology, 9:1347-59 PubMed

Kwiatkowski, A.V., D.A. Rubinson, E.W. Dent, J.E. van Veen, J.D. Leslie, J. Zhang, L. Mebane, U. Philippar, A.A. Burds, E. Pinheiro, R.T. Bronson, S. Mori, R. Fässler, and F.B. Gertler. (2007) Ena/VASP is required for neuritogenesis in the developing cortex.Neuron, 56:441-55 PubMed


2005

Kalil, K. and E.W. Dent (2005) Touch and go: guidance cues signal to the growth cone cytoskeleton.Current Opinions in Neurobiology,15: 521-26 PubMed


2004

Kalil, K. and E.W. Dent (2004) Hot +TIPS: Guidance cues signal directly to microtubules.Neuron, 42: 877-79 PubMed

Lebrand, C.*, E.W. Dent*, G.A. Strasser, L.M. Lanier, M. Krause T. Svitkina, G.G. Borisy and F.B. Gertler (2004) Critical Role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of Netrin-1.Neuron,42: 37-49. *Equal Contributions PubMed

Dent, E.W., A. Barnes, F. Tang and K. Kalil (2004) Netrin-1 and Sema 3A promote or inhibit cortical axon branching respectively by reorganization of the cytoskeleton.Journal of Neuroscience,24:3002-12 PubMed


2003

Dent, E.W. and F.B. Gertler (2003) Cytoskeletal dynamics and transport in growth cone motility and axon guidance.Neuron,40: 209-27 PubMed

Krause, M., E.W. Dent, J.E. Bear, J.J. Loureiro and F.B. Gertler. (2003) Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annual Review of Cell and Developmental Biology, 19: 541-64 PubMed

Erik W. Dent and Katherine Kalil. (2003) Dynamic Imaging of Neuronal Cytoskeleton. Methods in Enzymology, 361: 390-407 PubMed

Erik W. Dent, Fangjun Tang, and Katherine Kalil. (2003) Axon Guidance by Growth Cones and Branches: Common Cytoskeletal and Signaling Mechanisms. The Neuroscientist, 9: 343-353 PubMed

Fangjun Tang, Erik W. Dent, and Katherine Kalil. (2003) Spontaneous Calcium Transients in Developing Cortical Neurons Regulate Axon Outgrowth. Journal of Neuroscience, 23(3): 927-936 PubMed


2001

Szebenyi, G., Erik W. Dent, John L. Callaway, Chad Seys, Helen Leuth, and Katherine Kalil. (2001) Fibroblast Growth Factor-2 Promotes Axon Branching of Cortical Neurons by Influencing Morphology and Behavior of the Primary Growth Cone. Journal of Neurosciece, 21(11): 3932-3941 PubMed

Erik W. Dent and Katherine Kalil. (2001) Axon Branching Requires Interactions between Dynamic Microtubules and Actin Filaments. Journal of Neuroscience, 21(24): 9757-9769 PubMed


2000

Katherine Kalil, Gyorgyi Szebenyi, and Erik W. Dent. (2000) Common Mechanisms Underlying Growth Cone Guidance and Axon Branching. Journal of Neurobiology, 44: 145-158 PubMed


1999

Masabumi Nagashima, Erik W. Dent, Xiu-Zhen Shi, Katherine Kalil. (1999) Cortical Neurite Outgrowth and Growth Cone Behaviors Developmentally Regulated Cues in Spinal Cord Membranes. Journal of Neurobiology, 39: 393-406 PubMed

Erik W. Dent, John L. Callaway, Gyorgyi Szebenyi, Peter W. Baas, and Katherine Kalil. (1999) Reorganization and Movement of Microtubules in Axonal Growth Cones and Developing Interstitial Branches. Journal of Neuroscience, 19(20): 8894-8908 PubMed


1998

Gyorgyi Szebenyi, John L. Callaway, Erik W. Dent, and Katherine Kalil. (1998) Interstitial Branches Develop from Active Regions of the Axon Demarcated by the Primary Growth Cone during Pausing Behaviors. Journal of Neuroscience, 18(19): 7930-7940 PubMed

Erik W. Dent, Karina F. Meiri. (1998) Distribution of Phosphorylated GAP-43 (Neuromodulin) in Growth Cones Directly Reflects Growth Cone Behavior. Journal of Neurobiology, 35: 287-299 PubMed


1997

Qin He, Erik W. Dent, and Karina F. Meiri. (1997) Modulation of Actin Filament Behavior by GAP-43 (Neuromodulin) Is Dependent on the Phosphorylation Status of Serine 41, the Protein Kinase C Site. Journal of Neuroscience, 17(10): 3515-3524 PubMed


1995

Perry A. Brittis, Karina Meiri, Erik Dent, and Jerry Silver. (1995) The Earliest Pattern of Neuronal Differentiation and Migration in the Mammalian Central Nervous System. Experimental Neurology, 134: 1-12 PubMed


Book Chapters

2011

Dent, E.W. (2011) Working with actin: methodological approaches for the study of actin in neurons. In: The neurobiology of actin: from neurulation to synaptic function. L. Lanier and G. Gallo, eds. Springer, New York


2008

Dent, E.W. (2008) The multifaceted roles of actin in neuronal differentiation.In: The motile actin system in health and disease. C. Ampe and A. Lambrechts, eds. Research Signpost, Kerala, India


2006

Kalil, K., E.W. Dent and F. Tang (2006) Regulation of axon branching.In: Intracellular mechanisms for neuritogenesis.I. deCurtis, ed. Springer, New York